Monday, January 9, 2012

All about Bextra top 8 facts


All about Bextra top 8 facts

 
1-Bextra is a type of pain medication, called cox-2 selective non-steroidal anti-inflammatory drugs (nsaids), used to treat arthritis and menstrual pain. Why did fda strengthen the warnings?. Despite earlier warnings in the bextra label, the fda is still receiving reports of serious, potentially fatal, skin reactions such as sjs and ten. Patients known to have an allergy to sulfa products should not take bextra. Other cox-2 selective nsaids and traditional nsaids such as naproxen and ibuprofen also have a risk for these rare, serious skin reactions, but these serious side effects appear to occur more often for patients taking bextra than for other cox-2 agents. In addition, results from a new study of more than 1500 patients who had just had cardiac surgery show that patients treated with bextra for pain were more likely to have heart and blood clotting problems than other patients who did not receive any drug.


2-Bextra is approved to treat the signs and symptoms of osteoarthritis (oa), menstrual cramping. Bextra has previously been approved for relief from arthritis pain. Bextra is a once-daily treatment in an oral tablet formulation. More than 23 million Americans suffer from some form of arthritis. The most prevalent is oa, which affects approximately 21million americans. This chronic disorder is characterized by the degeneration of joint cartilage and bone, which can lead to severe pain and stiffness. Ra, which affects joint lining, cartilage and bone, affects over two million Americans. The approval of bextra is supported by results from clinical studies lasting from three to six months. In five double-blind trials with 3,918 subjects with oa of the knee or hip, bextra was significantly superior to placebo and comparable to a naproxen control, in treating pain and stiffness and improving functional measures. In four double-blind trials with 3,444 subjects with ra ,bextra demonstrated significantly better results than placebo and comparable results to naproxen in improving the tenderness andnumber of swollen joints and the level of pain. Bextra was evaluated for treatment of menstrual pain in two placebo-controlled studies.

3-Bextra is a cox-2 inhibitor, very similar to the more well known drug vioxx, which was used as an anti-inflammatory medication from december 2002 when it was first approved until December 2005 when it was removed from the market.   The cox-2 inhibitor celebrex also manufactured by Pfizer is still sold with strong warnings about possible links to heart attack and stroke.   when merck's similar drug vioxx was taken off the market September 30, 2004 some patients were actually switched by their doctors to bextra as an alternative but before long bextra warnings became very strong.   based on its formula it is probably a more dangerous drug than vioxx.   fortunately bextra was not used on a wide spread basis in Canada. The settlement was approved on November 29, 2011 by mr. Justice perell of the Ontario court despite objections from four class action members.   in addition to the link to heart attack and stroke shared with vioxx, bextra also triggered severe and sometimes deadly skin reactions (including Stephens Johnson syndrome) which are also being compensated in the settlement. The total Canadian settlement is for $12,000,000 but of that money about $5,000,000 is allocated to the class action lawyers' fees and expenses. Settlement amounts will range from $5,000 to $100,000 maximum per person. Significantly more will be paid to those who suffered adverse effects from bextra before there were strong warnings about it. The miskin law firm which represents more vioxx clients than any other law firm in canada has a small number of bextra cases and would be pleased to speak with any person who may be eligible for bextra compensation who is not represented by another lawyer.   claims packages must be submitted to the administrator within 180 days of the settlement approval. We expect our bextra clients will receive compensation in the spring of 2012.

4-Bextra is known to be a risk factor. Although the FDA and Pfizer directors were thought to be aware of the link between bextra use and sjs/ten it was approved and prescribed to millions. Moreover, it is only very recently that Pfizer have been ordered to add a black box -warning  the strongest warning possible - to bextra packaging providing information about the risks carried by the drug in relation to these skin diseases. The warning comes far too late for some people, who obliviously took the drug and suffered the effects.

5- Bextra is now under fire once again for a possible link with heart attacks, although this is still being investigated. The side effects caused by bextra have already resulted in a number of lawsuits against Pfizer, and it is likely that these lawsuits will continue to increase for the foreseeable future. Those that have taken or are still taking Bextra are urged to educate themselves on the symptoms and effects of sjs/ten and other bextra side effects. If you notice anything amiss you should seek medical assistance immediately. You may also be entitled to compensation if you have suffered the side effects of Bextra, and there are now many lawyers and law firms that specialize in drug litigation and Bextra lawsuits. If you feel that you may have grounds for compensation  or even if you are unsure as to whether you have a case it is advisable to contact an experienced Bextra lawyer. You will then be informed whether you have a valid case, and your lawyer can look at putting together a solid case in order to claim compensation for your medical expenses, pain, and suffering.

6-Bextra is also being linked to Stevens Johnson syndrome, a rare inflammatory skin disorder that can be life-threatening - up to 27 percent of those affected incur long term eye damage or vision loss, and up to 15 percent die. Bextra has only been studied in arthritis patients for up to a year. Doctors said it is too early to quantify the potential risk of bextra or of Pfizer's other cox-2 inhibitor celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients. Serious safety concerns about the entire class of cox-2 inhibitors, including bextra, have been raised due to the recent vioxx recall. Have you been taking bextra? if so, you may have a claim for a lawsuit. Contact a bextra attorney in your area now.

7-Bextra is a "cox-2" selective non-steroidal anti-inflammatory drug) and safety concerns of an increased risk of rare but serious skin reactions in patients taking bextra. Do not take bextra without first talking to your doctor if you have experienced asthma, hives, or an allergic reaction after taking a sulfa-based medication such as sulfamethoxazole (bactrim, septra, gantanol, and others) or sulfisoxazole (gantrisin); aspirin; or another nsaid such as celecoxib (celebrex), ibuprofen (motrin, advil, nuprin, and others), naproxen (aleve, naprosyn, anaprox), ketoprofen (orudis kt, orudis, oruvail), diclofenac (voltaren, cataflam), diflunisal (dolobid), etodolac (lodine, lodine xl), fenoprofen (nalfon), flurbiprofen (ansaid), indomethacin (indocin), ketorolac (toradol), meloxicam (mobic), nabumetone (relafen), oxaprozin (daypro), piroxicam (feldene), sulindac (clinoril), or tolmetin (tolectin). You may experience a similar reaction to bextra. *****Notify your doctor immediately if you develop abdominal pain, tenderness, or discomfort; nausea; bloody vomit; bloody, black, or tarry stools; unexplained weight gain; swelling or water retention; fatigue or lethargy; a skin rash; itching; yellowing of the skin or eyes;"flu-like" symptoms; or unusual bruising or bleeding. These symptoms could be early signs of dangerous side effects. Serious skin reactions have occurred in patients taking bextra. These reactions tend to occur within the first two weeks of treatment, but may occur at any time during treatment. Stop taking bextra and contact your doctor immediately if you develop a skin rash; hives; itching; difficulty breathing; swelling of the lips, tongue or face; or other symptoms of an allergic reaction. Bextra was withdrawn from the u. Bextra is in a class of drugs called non-steroidal anti-inflammatory drugs ( nsaids). Bextra works by reducing substances in the body that cause inflammation, pain, and fever.

8-Bextra is contraindicated for the treatment of post-operative pain immediately following coronary artery bypass graft surgery and should not be used in this setting (see. Cardiovascular safety analysis from osteoarthritis and rheumatoid arthritis studies. Randomized controlled clinical trials with bextra longer than one year have not been conducted, nor have studies powered to detect differences in cardiovascular events in a chronic setting been conducted. In an analysis of 10 randomized controlled clinical studies in osteoarthritis and rheumatoid arthritis, 4531 patients received bextra in doses ranging from 10 mg to 80 mg for periods of 6 to 52 weeks. The majority of these patients received bextra for 12 weeks or less. This analysis compared the incidence of serious cardiovascular events in bextra-treated patients with the incidence of these events in patients receiving placebo (n=1142) or nsaid therapy (n=2261). In this analysis, no apparent differences were detected in the exposure-adjusted serious cardiovascular thromboembolic event rates between patients receiving bextra, placebo and nsaids.

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